Interspecific hybrids can be formed through allopolyploidization. Synthetic hexaploid wheats (SHW) have been created in breeding programs through the intentional crossing of tetraploid and diploid species. In this study, quantitative genetics tools developed to predict cross performance within a species were applied to predict the phenotypes of SHW for four major quantitatively inherited diseases using the data contained in this dataset. The results of the analysis are presented in the accompanying article.