This study was conducted with the objective to assess the performances of hybrids developed from early and medium maturing lowland adapted Ethiopian sorghum inbred lines. A total of 95 hybrids and three checks were tested using alpha lettuce design with two replications at Meiso and Sheraro. All agronomic practices were done on time as recommended. Based on the results obtained from the analysis positive and significant GCA values among the female lines were recorded by ICSV96143, ICSR93034, IESV92168-DC and ETSL101565. Likewise, tester TX623A were identified as most promising parents having good general combining ability for grain yield and almost all its major yield components. Similarly, for grain yield, 15 hybrid combinations had significant advantage over their respective standard check Melkam. Among these hybrids the highest was obtained from MARC6A x IESV23010DL (78%) followed by TX623A x ETSL101859 (71%) and TX623A x ETSL100684 (67%). The information generated from the present study can be used for breeders who want to improve yield and yield-contributing traits of sorghum by understanding the genetic relationship among inbred lines.