Salinity is one of the major environmental problem that lead to deterioration of agricultural land and, as a result, to reduction in crop productivity. Evaluation of sorghum varieties/lines for salt tolerance were conducted with the objectives to evaluate and identify salinity stress tolerance and to determine the effect of salinity at different levels of NaCl in Raya valley, northern Ethiopia. The screening procedures were conducted at three stages; germination, seedling and field experiment through exposing to salt stress condition. Initially, 46 varieties/lines of sorghum were placed in Petri plates using 0 and 20 dS m-1 level of NaCl and better performing were selected based on their total germination percentage and germination stress tolerance index. Then, control (0 dS m-1) and three salinity levels (10, 15 and 20 dS m-1) of NaCl were prepared at germination and seedling stages. Results indicated that, all investigated traits were affected by salt stress at germination and seedling stages. Similarly, soil salinity reduced yield and yield components of sorghum at field experiments. Both Meko and 76T1#23 were more yielded than the national average compared to the tested sorghum varieties in the two consecutive cropping seasons. Thus, Meko and 76T1#23 were promising varieties as indicated by all investigated traits and hence, recommended for yield and yield traits maximization Raya valley. Therefore, these varieties should be validated and demonstrated to more numbers of farmers in larger plots to recommend to extension users.